Friday, December 21, 2012

Longform?s Best Sex Stories of 2012

This week, we?ll be sharing our favorite articles of the year on Slate. For our full list?including the top 10 of the year, plus picks in sports, politics, tech and more?check out Longform?s Best of 2012.

Demystifying a ubiquitous Internet presence.

?If you think cam girls?those flirty naked characters that plague porn site pop-up ads?are raking in easy money, you're right. If you think cam girls are bleakly stripping online out of desperation, you're also right. Peel away the sex and pixels and money and you're left with the cloudy truth about the Internet's relationship status with these on-demand entertainers: it's complicated.

?You've looked at porn online, which means you've likely been propositioned by advertisements for cam girl networks. They invade your peripheral vision; they pop up behind your window. The women wait for you to start staring, and, just when you're interested, they hit you up for money. You've seen them sitting at their keyboards, wearing barely anything, winking at you, typing to nobody in particular with thin, lethargic arms: bored and conventionally beautiful. The ads, with flirty video that might be live or recorded years ago, shout at you with promises of ?Live Sex Chat? and ?Sex Shows,? with both amateurs and ?pornstars? alike. It's a web red light district, and unlike some gaudy Dutch strip or seedy sidewalk, you're completely anonymous. The sex comes to you.?

Absolute Beginners
Bethany Cosentino, Krista Burton, Lena Dunham, Liz Phair, Miranda July, Pamela Des Barres, Sarah Silverman, Shannon Woodward ? Rookie

Eight women remember their first time.

158294209 Lena Dunham talks sex

Jason Merritt/Getty Images.

?Lena Dunham: When I was about nine I wrote a vow of celibacy on a piece of paper and ate it. I promised myself, in orange magic marker, that I would remain a virgin until I graduated from high school. This seemed important because I knew my mother had waited until the summer after she graduated and also Angela Chase seemed pretty messed up by her experience at that flophouse where high school kids went to copulate. If my relationship to liver pat? was any indication, and I had recently eaten so much that I barfed, then my willpower was very bad, and I needed something stronger than resolve to prevent me from having intercourse too early in life.

?Turns out, this was an unnecessary precaution. The opportunity never arose in high school, nor even during the first year of college, save for a near-miss with a stocky kid I knew who was home visiting New York City from the Air Force Academy?that encounter went far enough that I had to fish a mint-colored, never-used condom out from behind my dormitory bunk bed the next day. I transferred to Oberlin my sophomore year, a small liberal arts school in Ohio that was known for having been the first college to admit both women and men, as well as for its polyamorous, bi-curious student body. I was neither, but it did seem like a good environment in which to finally get the ball rolling. I really felt like the oldest virgin in town, save for a busty riot grrrl from Olympia, Washington, who was equally frustrated; she and I would often meet up in our nightgowns to discuss.

?I was pretty sure I had already broken my hymen in high school, crawling over a fence in Brooklyn in hot pursuit of a cat that clearly didn?t want to be rescued. So the event would only be psychologically painful.?

Sex and status disclosure in the age of Grindr and undetectable HIV-levels.

?The first guy I ever turned down on Grindr for having HIV, my patient zero if you will, is all kinds of hot: hot in the face, hot in the body and hotheaded. In May, he asked me to come over and make out. We chatted a little bit more, he told me about his status and I slipped out of the conversation, just like that. Randomly in July, I noticed him at a movie theater: On Grindr and online, people lie with pictures all the time, choosing ones that distort their appearance in a captured second, but I was able to pick Miguel right out of a crowd. His picture is a symbol of habitual honesty, maybe, but also because he's so attractive, he has no reason to lie.

? ?This always happens: someone will feel bad and then they'll see me out and they'll be like, ?Oh my god, you're so fucking hot,? ? Miguel told me while we waited for our table outside of a Chelsea brunch spot one Saturday in early July after I reconnected and asked him to talk to me.

?Miguel told me that being turned down for sex because he's HIV-positive is something that happens ?all the time,? and that ?almost every time, the minute someone gets to know me, their mind changes.? Exposure to a gay friend often converts homophobes swiftly; the same can be said of an HIV-positive guy meeting others who are fearful. It's somewhat reassuring that that's all it takes in many cases, but it also underlines the exponential burden put upon positive guys. They are either in a constant state of proving themselves socially or they are sitting on a secret.?

The Ayatollah Under the Bed(sheets)
Karim Sadjadpour ? Foreign Policy

Politics, sex, and political sex in Iran.

?Perhaps it's not entirely surprising that Iran's Shiite fundamentalists?not unlike their evangelical Christian, Catholic, Orthodox Jewish, and Sunni Muslim counterparts?spend an inordinate amount of time pondering sexuality. They are human, after all. But the sexual manias of Iran's religious fundamentalists are worthy of greater scrutiny, all the more so because they control a state with nuclear ambitions, vast oil wealth, and a young, dynamic, stifled population. Yet for a variety of reasons?fear of becoming Salman Rushdie, of being labeled an Orientalist, of upsetting religious sensibilities?the remarkable hypocrisy of the Iranian regime is often studiously avoided.

?That's a mistake. Because religion is politics in a theocracy like Iran, uninformed or antiquated notions of sexuality aren't just confined to the bedroom?they pervade the country's seminaries, military barracks, boardrooms, courtrooms, and classrooms. A common aphorism among Iranians is that before the revolution, people partied outside the home and prayed inside, while today they pray outside and party inside. This reverse dichotomy is true of a lot of social behavior in Iran. For many Iranians, this perverse state of affairs is now so ingrained, such an inherent aspect of daily interactions with Iranian officialdom, that it is no longer noteworthy. For those in the West who seek to better understand what makes Tehran tick, though, the regime's curious fixation on sex cannot be ignored.?

Sex in the Olympic Village.

?Home to more than 10,000 athletes at the Summer Games and 2,700 at the Winter, the Olympic Village is one of the world's most exclusive clubs. To join, prospective members need only have spectacular talent and ?we long assumed?a chaste devotion to the most intense competition of their lives. But the image of a celibate Games began to flicker in '92 when it was reported that the Games' organizers had ordered in prophylactics like pizza. Then, at the 2000 Sydney Games, 70,000 condoms wasn't enough, prompting a second order of 20,000 and a new standing order of 100,000 condoms per Olympics.

?Many Olympians, past and present, abide by what Summer Sanders, a swimmer who won two gold medals, a silver and a bronze in Barcelona, calls the second Olympic motto: ?What happens in the village stays in the village.? Yet if you ask enough active and retired athletes often enough to spill their secrets, the village gates will fly open. It quickly becomes clear that, summer or winter, the games go on long after the medal ceremony. ?There's a lot of sex going on,? says women's soccer goalkeeper Hope Solo, a gold medalist in 2008. How much sex? ?I'd say it's 70 percent to 75 percent of Olympians,? offers world-record-holding swimmer Ryan Lochte, who will be in London for his third Games. ?Hey, sometimes you gotta do what you gotta do.? ?


For more of the year?s best writing, check out Longform?s Best of 2012.

Source: http://feeds.slate.com/click.phdo?i=90d51895713f8d2d3c1a7a6475b0dfbf

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Source: http://www.facebook.com/Fox4DFW/posts/310341592416498

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Craig Levein opens legal proceedings with Scottish FA | The Sun ...

CRAIG LEVEIN has opened legal proceedings against the Scottish FA.

The flop Tartan Army boss was ?relieved of his duties? on November 5 following a disappointing start to their World Cup qualifying campaign.

Last month it emerged that Levein was seeking legal advice.

And he has today served the SFA with a writ despite the governing body insisting it would honour their former manager?s contract, with payments over the next 20 months.

An SFA statement read: ?Regrettably, the Scottish FA has received notification from lawyers representing Craig Levein that their client has served a writ on the Association.

?This notification has been received despite the Scottish FA?s offer to honour Craig?s contract in full, an offer that was made immediately upon the board?s decision to relieve Craig of his duties on November 5, 2012.

?The Scottish FA has since received notification that Craig has chosen to resign, thereby foregoing the offer made to honour his contract in full.

?In the notification received, failure to make a proposal in lieu of compensation has been cited.

?It is the view of the Scottish FA that no such offer is required given Craig?s decision to resign, especially since an offer of mediation was rejected by his legal representatives.

?We will make no further comment at this time.?

Source: http://www.thesun.co.uk/sol/homepage/sport/football/4706089/Craig-Levein-opens-legal-proceedings-with-Scottish-FA.html

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Better approach to treating deadly melanoma identified

Dec. 19, 2012 ? Scientists at The University of Manchester have identified a protein that appears to hold the key to creating more effective drug treatments for melanoma, one of the deadliest cancers.

Researchers funded by Cancer Research UK have been looking at why new drugs called "MEK inhibitors," which are currently being tested in clinical trials, aren't as effective at killing cancer cells as they should be.

They discovered that MITF -- a protein that helps cells to produce pigment but also helps melanoma cells to grow and survive -- is able to provide cancer cells with a resistance to MEK inhibitors.

Dr Claudia Wellbrock and her team at the Wellcome Trust Centre for Cell-Matrix Research compared human melanoma cells that respond to the drug to cells that don't. They discovered that the cells that didn't respond to the drug contained higher levels of the protein SMURF2.

The researchers reduced the level of SMURF2 in the melanoma cancer cells and then treated the tumour with the MEK inhibitor. They found a 100 fold increase in the sensitivity of the cells to the drug. It appears that removing SMURF2 radically decreases the level of MITF in melanoma cells, making the MEK inhibitor a lot more powerful.

Using mice with tumours the team found that over a three week period there was a substantial decrease in tumour growth when the removal of SMURF2 was used in combination with MEK inhibitors.

Dr Wellbrock says: "Much of cancer research is now focussed on finding new drug combinations. It's recognised that cancers frequently find new ways to combat even the most novel and highly efficient drug treatments, so we are now focussing on targeting the mechanisms that allow the cancer cells to overcome the drug effects. We're very excited about the potential for this new approach that has proved to be so effective in our experiments."

One of the drawbacks of the MEK inhibitor drug is that it targets all cells. MEK (MAP/ERK kinase protein) is present in all cells but cancer cells have overactive MEK. This means the drug must be used in small doses and for a lengthy period to avoid harming healthy cells. By reducing SMURF2 to increase the drug's effectiveness smaller doses could be given over a shorter time period, reducing the level of toxicity in healthy cells.

Dr Wellbrock says: "If we can reduce the toxicity to all cells it will mean cancer treatments are less harmful to patients. It's vital that we improve the treatments for melanoma which is the fifth most common cancer in the UK. By the time many people are diagnosed with melanoma the cancer has already started to spread and advanced tumours can be highly resistant to conventional cancer treatments. The development of resistance to new drugs has also been a major drawback. If we can identify more potent and less toxic drug combinations to tackle melanoma then we could save thousands of lives."

This study was funded in part by Cancer Research UK and the results have been published in the Journal of the National Cancer Institute.

Talking about the research Dr Julie Sharp from the charity said: "Recently there have been some really exciting developments in treating melanoma -- but new approaches that tackle the problem of resistance are still needed. This type of research will be a key focus of the planned new Manchester Cancer Research Centre which will bring together a wide range of research expertise to revolutionise cancer treatment."

The next step for Dr Wellbrock will be to find a drug that can reduce the activity of SMURF2 in cancer cells. The Manchester research team are now screening drug libraries for an existing drug that may already be approved for use for a different illness.

It's hoped that identifying a drug to use in combination with MEK inhibitors will provide a much more powerful and ultimately more successful approach to treating melanoma.

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Story Source:

The above story is reprinted from materials provided by Manchester University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. M. P. Smith, J. Ferguson, I. Arozarena, R. Hayward, R. Marais, A. Chapman, A. Hurlstone, C. Wellbrock. Effect of SMURF2 Targeting on Susceptibility to MEK Inhibitors in Melanoma. JNCI Journal of the National Cancer Institute, 2012; DOI: 10.1093/jnci/djs471

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/khn6WUoD1fQ/121219082813.htm

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Tuesday, December 18, 2012

NHL lawsuit assigned to former federal prosecutor

NEW YORK (AP) ? The NHL's lawsuit against its players was assigned to a relatively new federal judge who is a longtime New York Yankees fan and a former federal prosecutor.

The sides didn't talk Sunday, the 92nd day of a lockout that is threatening to wipe out an entire NHL season for the second time in nine years. NHL players started voting on whether to have their union give up collective bargaining rights, a "disclaimer of interest" that could be a precursor to an antitrust suit.

The league argued in a 43-page suit Friday in federal court in Manhattan that the union's actions were a bargaining maneuver and asked that the lockout be declared legal. The case was assigned to U.S. District Judge Paul A. Engelmayer, who joined the bench in July 2011.

The 51-year-old is a graduate of Horace Mann School, Harvard College and Harvard Law School.

He spent a year between college and graduate school as a reporter for The Wall Street Journal. After clerking for Supreme Court Justice Thurgood Marshall, he had two stints in the U.S. Attorney's office in Manhattan, rising to chief of the major crimes unit. He also worked in the Solicitor General's office in Washington, D.C.

One of his more prominent cases occurred in 1999, when he led the prosecution of Lawrence X. Cusack III, convicted on 13 counts on mail and wire fraud stemming from the sale of forged documents claiming President John F. Kennedy paid hush money to keep secret an affair with Marilyn Monroe. Cusack was sentenced to 10 years, 3 months in prison and ordered to pay $7 million restitution.

Two years earlier, Engelmayer prosecuted a Los Angeles woman, Autumn Jackson, who was convicted of conspiracy and crossing state lines to commit a crime for threatening to tell tabloids she was Bill Cosby's out-of-wedlock child unless he paid her $40 million. Jackson was sentenced to 26 months in prison. Cosby denied he was Jackson's father but admitted having an affair with her mother and providing more than $100,000 in financial support.

Engelmayer worked from 2000-11 with the New York law firm now known as WilmerHale before he was nominated for the bench by President Barack Obama and confirmed by the Senate.

In his most notable decision thus far, Engelmayer ruled a provocative ad that equates Muslim radicals with savages is protected speech under the First Amendment. New York's Metropolitan Transportation Authority initially refused to run the ad, saying it was "demeaning."

Source: http://news.yahoo.com/nhl-lawsuit-assigned-former-federal-prosecutor-224303378--nhl.html

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Microscopic beauties found in a slimeball

Colonial rotifers get jiggy with it in a video entered in the Olympus BioScapes Digital Imaging Competition. Australian high-school teacher Ralph Grimm assembled the video from microscopic images.

By Alan Boyle

You might not think something wonderful can be found in a ball of slime ? but Ralph Grimm's prize-winning video of the creatures living in a bit of pond scum proves it's possible.

Grimm's microscopic view of a colony of rotifers, complete with googly eyespots, won first prize in this year's Olympus BioScapes Digital Imaging Competition. More than 2,000 pictures of tiny life-science subjects were submitted from all over the world ? and today Olympus announced that Grimm led the top-10 list. You can see all 10 prize-winners, plus a selection of the entries receiving honorable mentions, in our slideshow.

Grimm, a 45-year-old high-school teacher from the Australian town of Jimboomba, says he found the microscopic colony in a bit of drab-looking leaf debris that he dredged up from a pond on his property.?"They look very plain," Grimm told me. "They look like slimeballs. You wouldn't take notice unless you knew what you were looking for."


Fortunately, Grimm knew exactly what he was looking for, thanks to his long-running passion for microscopy. He recalled that he got his first microscope as a gift at the age of 7. "Once I learned to use the instrument, I got hooked on it. It's followed me along all my life," he said.

When Grimm got the slimeball under his microscope and cranked the magnification to 200x, he couldn't believe his eyes. "I had never seen this species of rotifer before," he said. Rotifers are tiny animals that live primarily in fresh water and gobble up gunk. As I mentioned last year in an item about the critters, there's a good chance that you've swallowed down more than a few rotifers if you drink unfiltered tap water. Some might think they're icky, but Grimm thought they were so cool that he set aside everything else he had planned for the day.

"Forget about lunch. Don't worry about breakfast," he said. "This is how I spent the entire day, just filming." After capturing gigabytes' worth of pictures, Grimm figured he had a good entry for the Olympus contest. And he was right.

As the first-prize winner, Grimm is receiving $5,000 worth of Olympus camera and microscope equipment, plus an expense-paid trip to San Francisco to bask in his glory. Arlene Wechezak's picture of red algae earned her the $2,500 second prize, and Igor Siwanowicz won the $1,500 third prize.

Click through the top images from the 2012 Olympus BioScapes International Digital Imaging Competition, which features microscopic images of life science subjects

Siwanowicz's ultra-close-up view of a fern wasn't the only picture recognized by the judges: He also scored three honorable mentions for his beautiful portraits of a feathery amphipod appendage, a moth's curled-up proboscis and an oak lace bug.

Siwanowicz, a researcher at the Howard Hughes Medical Institute's Janelia Farm research campus in Virginia, uses a laser-scanning confocal microscope and a palette of pigments to bring out the details in his small-scale subjects.?"To our eyes, the specimens appear very different from the final image," Siwanowicz told me in an email. "Usually they are colorless, sometimes showing red hue, depending on the intensity of staining. The samples of invertebrate exoskeletons stained with Congo Red dye are very often bright red."

He assigns different colors to the different wavelengths given off when his subjects are illuminated. "Assignment of the color in the captured image to any given channel is purely arbitrary; however, I do assign blue to the channel recording light of the shortest wavelength, green and red in similar fashion, in the 'natural' order," he said. "Combining the three channels into one produces the whole palette of colors. That is the closest to real representation of colors achievable with this microscopic technique ? in effect, it is like the microscope had trichromatic?'vision,' just as we do."

Click through the slideshow to see what Siwanowicz is talking about?? and grab your red-blue glasses to see the 3-D effect in this bonus picture of the oak lace bug. If you're in need of some red-blue specs, stay tuned: We'll be running a 3-D glasses giveaway on the Cosmic Log Facebook page later today.

Igor Siwanowicz

This 3-D photomicrograph provides a frontal view of the oak lace bug, a common pest found in oak trees. Wear red-blue glasses to see the 3-D effect.

More small wonders:


Alan Boyle is NBCNews.com's science editor. Connect with the Cosmic Log community by "liking" the log's?Facebook page, following?@b0yle on Twitter?and adding the?Cosmic Log page?to your Google+ presence. To keep up with Cosmic Log as well as NBCNews.com's other stories about science and space, sign up for the Tech & Science newsletter, delivered to your email in-box every weekday. You can also check out?"The Case for Pluto,"?my book about the controversial dwarf planet and the search for new worlds.

Source: http://cosmiclog.nbcnews.com/_news/2012/12/17/15958431-how-beauty-was-found-in-a-slimeball?lite

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